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Cryoglobulin Screen with Reflex to Cryoglobulin Panel [37358]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
CRYOG
Alias/See Also
37358
CPT Codes
82595
Includes
If cryoglobulin is present (positive), it is identified. Positives are semi-quantitated (as % cryoglobulin) by cryocrit.
When Cryoglobulin Screen is positive, Cryoglobulin Panel (Cryocrit Immunofixation, Cryocrit Immunodiffusion and Rheumatoid Factor) will be performed at an additional charge (CPT Code(s): 86334, 86329, 86431).
When Cryoglobulin Screen is positive, Cryoglobulin Panel (Cryocrit Immunofixation, Cryocrit Immunodiffusion and Rheumatoid Factor) will be performed at an additional charge (CPT Code(s): 86334, 86329, 86431).
Preferred Specimen
10 mL serum collected in a red-top tube (no gel)
Patient Preparation
Overnight fasting is required.
Minimum Volume
3.5 mL
Instructions
Stability restrictions: Sample has only 72 hr stability. Only draw Mondy through Thursday.
Collect 20 mL of fasting whole blood specimen in a red-top tube (no gel). 10 mL serum required: 3.5 mL minimum. Avoid hemolysis. -Allow serum sample to clot for one (1) hour in a 37°C water bath, oven, incubator, or heat block. -After clotting, centrifuge the specimen for 10 minutes at 3000 rpm utilizing one of the 3 options below: 1) In a "warm" centrifuge at 37° C; or 2) In a bench-top centrifuge placed in a "warm room" at 37°C; or 3) At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 2000 rpm. -After centrifuging, decant serum into a screw-capped vial -Transport at room temperature. Note: No other tests can be added to the tube; cryocrit and cryoglobulin evaluation only
Collect 20 mL of fasting whole blood specimen in a red-top tube (no gel). 10 mL serum required: 3.5 mL minimum. Avoid hemolysis. -Allow serum sample to clot for one (1) hour in a 37°C water bath, oven, incubator, or heat block. -After clotting, centrifuge the specimen for 10 minutes at 3000 rpm utilizing one of the 3 options below: 1) In a "warm" centrifuge at 37° C; or 2) In a bench-top centrifuge placed in a "warm room" at 37°C; or 3) At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 2000 rpm. -After centrifuging, decant serum into a screw-capped vial -Transport at room temperature. Note: No other tests can be added to the tube; cryocrit and cryoglobulin evaluation only
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable
Refrigerated: Unacceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Icteric • Serum separator tube (SST)
Methodology
Cryocrit • Electrophoresis • Immunodiffusion (ID) • Immunofixation (if needed) • Rate Nephelometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun-Fri; Report available: 6-8 days
Reference Range
| Cryoglobulin, QL | Negative in normal individuals |
Clinical Significance
Cryoglobulins are proteins that precipitate from serum at temperatures below 37° C. Most precipitate when serum is cooled at 4° C, but some gel even at room temperature. The gel or precipitate must redissolve at 37° C to be classified as a cryoglobulin.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Last Updated: November 29, 2021
