Calprotectin, Stool [16796]

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

Alias/See Also

CPT Codes

Preferred Specimen
3 grams (0.3 gram minimum) solid stool collected in a clean leak-proof plastic screw-cap container without preservative

Liquid or semi-liquid stool

Minimum Volume
0.3 grams

Other Acceptable Specimens
Liquid or semi-liquid stool collected in a Quest standard stool container without preservative, or a clean, leak-proof plastic screw-cap container without preservative

Collect stool specimen in a clean leak-proof plastic screw-cap container without preservative.

Transport Temperature

Specimen Stability
Room temperature = Stable for 6 days. However due to the sample type, it is not recommended to keep stool sample at Room Temperature.
Refrigerated = 7 days
Frozen = 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Stool specimen collected in a container with fixative or preservative • Stool specimen collected during surgical procedure • Other specimen rather than raw stool sample


Setup Schedule

Report Available
4-5  days

NSAIDs may cause elevated results.

Reference Range
<50 mcg/g Normal
50-120 mcg/g Borderline
>120 mcg/g Elevated

Clinical Significance
Calprotectin is a non-specific marker of bowel inflammation. Subsequent to white blood cell migration into the intestine, this neutrophil protein may be detected in the stool. Thus, fecal calprotectin levels may assist in diagnosis of inflammatory bowel disease; Crohn's disease and ulcerative colitis and other disorders characterized by bowel inflammation. It can also be used as an aid in the differentiation of IBD from irritable bowel syndrome.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675

Last Updated: October 17, 2022

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.