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Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot [90138]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
NEURAB
Alias/See Also
90138;
Paraneoplastic Syndrome AB Panel
Paraneoplastic Syndrome AB Panel
CPT Codes
86255 (x3)
Includes
Neuronal Nuclear (Hu) Antibody with Reflex to Titer and Western Blot; Neuronal Nuclear (Yo) Antibody with Reflex to Titer and Western Blot; Neuronal Nuclear (Ri) Antibody with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is positive, Hu Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, Western Blot is positive, Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA is positive, Yo Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot is positive, Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA is positive, Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Ri Antibody, Western Blot is positive, Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Hu Antibody Screen, IFA is positive, Hu Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, Western Blot is positive, Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA is positive, Yo Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot is positive, Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA is positive, Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Ri Antibody, Western Blot is positive, Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
Preferred Specimen
1.5 mL serum
Patient Preparation
Overnight fasting is preferred
Minimum Volume
0.6 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Wed, Fri; Report Available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Last Updated: November 30, 2021
