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Vancomycin Level
Test CodeVANCP, VANCR, VANCT
Alias/See Also
Vancomycin Peak, VANCP, Vancomycin Trough, VANCT, Vancomycin Random, VANCR
CPT Codes
80202
Preferred Specimen
Light GREEN (PST)
Other Acceptable Specimens
Serum (Red), Gold (SST), Orange (OJ), Tiger Top
Plasma: Purple EDTA(Lav), GRN (Heparin)
Plasma: Purple EDTA(Lav), GRN (Heparin)
Instructions
Collect a trough sample just before the next scheduled dose.
When adjusting dosage, measure peak and trough levels during the same dosing interval.
To obtain a vancomycin concentration that best represents the peak tissue level, draw the sample 0.5 - 2.0 hours after an infusion.
When adjusting dosage, measure peak and trough levels during the same dosing interval.
To obtain a vancomycin concentration that best represents the peak tissue level, draw the sample 0.5 - 2.0 hours after an infusion.
Specimen Stability
Sample Stability: Preferably, blood specimens should be separated and tested immediately after collection, or separated specimens should be frozen. Thaw frozen specimens and test them immediately.
- Refrigerator Temperature: Store the serum or plasma refrigerated at 2-8°C. for up to 3 days.
- Freezer Temperature: Store serum or plasma frozen (≤-20°C) for up to 1 month
Setup Schedule
24x7
Report Available
24x7
Limitations
AMR: 2-150 ug/mL
Reference Range
Reference Range-Trough: 5.0-20.0 ug/mL; Critical: > 25.0 ug/mL
Reference Range-Peak: 30.0-50.0 ug/mL; Critical: > 50.0 ug/mL
Reference Range-Random: 5.0-50.0 ug/mL: Critical: > 50.0 ug/mL
Reference Range-Peak: 30.0-50.0 ug/mL; Critical: > 50.0 ug/mL
Reference Range-Random: 5.0-50.0 ug/mL: Critical: > 50.0 ug/mL
Clinical Significance
Vancomycin is an aminoglycoside antibiotic used to treat infections caused by many different bacteria.
Monitoring serum vancomycin concentrations, along with careful clinical assessment, is the most effective means of ensuring adequate therapy for several reasons:
Monitoring serum vancomycin concentrations, along with careful clinical assessment, is the most effective means of ensuring adequate therapy for several reasons:
- Individual patients exhibit a high degree of variability in response to a given dose of vancomycin in terms of the volume of distribution and the rate of drug clearance from plasma.
- The risk of ototoxicity and nephrotoxicity from vancomycin is increased in patients with impaired renal function and in patients receiving concurrent aminoglycoside therapy.
- Patients with impaired renal or hepatic function, dialysis patients, morbidly obese patients, patients receiving concurrent aminoglycoside therapy, and pediatric or elderly patients should be monitored closely while on vancomycin therapy.
Performing Laboratory
CRMC Laboratory
CCMC Laboratory
FHSH Laboratory
