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Lithium Level
MessageIt is recommended that a standardized 12hr-post dose serum lithium concentration be used to assess adequate therapy. Peak concentration is reached 2 to 4 hours after oral dosing.
Test Code
LITH2
CPT Codes
80178
Preferred Specimen
GOLD (SST)
Other Acceptable Specimens
Serum or Plasma: RED (Red), Purple (Lav)
Instructions
No Lithium Heparin tubes.
Specimen Stability
Serum or plasma should be separated from cells if storage of more than 4 hours is anticipated. Lithium samples are stable for one week when stored at 2 - 25°C and stable indefinitely when frozen < -20°C.
Methodology
Beckman AU
Setup Schedule
24x7
Reference Range
0.5-1.5 mmol/L; Critical >1.5 mmol/L
Clinical Significance
"Lithium is widely used in the treatment of manic depressive psychosis. Administered as Lithium Carbonate, it is completely absorbed by the gastro-instestinal tract, peak serum levels occur 2 to 4 hours after an oral dose. The half life in serum is 48 to 72 hours, and it is cleared through the kidneys (excretion parallels that of sodium). Reduced renal function can prolong clearance time. Lithium acts by enhancing the uptake of neurotransmitters, which produces a sedative effect on the central nervous system. Serum lithium concentrations are carried out essentially to ensure compliance and to avoid toxicity. Early symptoms of intoxication include apathy, sluggishness, drowsiness, lethargy, speech difficulties, irregular tremors, myoclonic twitchings, muscle weakness, and ataxia.
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Performing Laboratory
CRMC Laboratory
