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Gentamicin Level
Test CodeGENTT, GENTP, GENTR
Alias/See Also
Gentamicin Peak, Gentamicin Trough, Gentamicin Random, GENTT, GENTP, GENTR
CPT Codes
80170
Preferred Specimen
Serum: RED (RED)
Patient Preparation
Collect a trough sample just before the next scheduled dose.
When adjusting dosage, measure peak and trough levels during the same dosing interval.
Other Acceptable Specimens
Serum: Gold (SST), Serum (Red) or Orange (OJ) or Tiger Top Serum
Plasma: Heparin (GRN), EDTA (Lav)
Plasma: Heparin (GRN), EDTA (Lav)
Specimen Stability
Store refrigerated at 2-8°C for up to six weeks
Stored frozen (<-20°C) for up to six months. If sample is frozen, thaw at a room temperature of 15-25°C. Vigorously mix all samples: Vortex for at least 30 seconds. Centrifuge sample at > 2000 rpm for 15 minutes.
Stored frozen (<-20°C) for up to six months. If sample is frozen, thaw at a room temperature of 15-25°C. Vigorously mix all samples: Vortex for at least 30 seconds. Centrifuge sample at > 2000 rpm for 15 minutes.
Methodology
Beckman AU
Setup Schedule
24x7
Report Available
24x7
Limitations
AMR: 0.3-100 ug/mL
Reference Range
Gentamicin Trough:
Trough < 3 months age: 0.0-1.9 ug/mL: Critical: > 2.0 ug/mL
Trough > 3 months age: 0.0-1.9 ug/mL: Critical: > 3.0 ug/mL
Gentamicin Peak:
Peak < 3months old: 5.0-12.0 ug/mL: Critical: >12.0 ug/mL
Peak >3 months old: 5.0-10.0 ug/mL: Critical: >12.0 ug/mL
Gentamicin Random:
Random < 3 months age: 0.0-12.0 ug/mL: Critical: > 12.0 ug/mL
Random > 3 months age: 0.0-10.0 ug/mL: Critical: > 12.0 ug/mL
Trough < 3 months age: 0.0-1.9 ug/mL: Critical: > 2.0 ug/mL
Trough > 3 months age: 0.0-1.9 ug/mL: Critical: > 3.0 ug/mL
Gentamicin Peak:
Peak < 3months old: 5.0-12.0 ug/mL: Critical: >12.0 ug/mL
Peak >3 months old: 5.0-10.0 ug/mL: Critical: >12.0 ug/mL
Gentamicin Random:
Random < 3 months age: 0.0-12.0 ug/mL: Critical: > 12.0 ug/mL
Random > 3 months age: 0.0-10.0 ug/mL: Critical: > 12.0 ug/mL
Clinical Significance
Gentamicin is an aminoglycoside antibiotic that acts by inhibiting bacterial protein synthesis. It is used to treat serious infections due to many aerobic and anaerobic types of bacteria.
Monitoring gentamicin concentrations in serum, along with careful clinical assessment, is the most effective means of ensuring adequate therapy for the following reasons:
Monitoring gentamicin concentrations in serum, along with careful clinical assessment, is the most effective means of ensuring adequate therapy for the following reasons:
- Gentamicin concentration in serum correlates better with antibacterial activity than does dosage.
- A standard dose of gentamicin does not always yield a predictable serum level because drug concentration also depends on the patient’s volume of distribution and on drug elimination. These factors are influenced by the mode of administration, the volume of extracellular fluid, renal function, and physiological changes during therapy.
- Gentamicin has a narrow range of safe and effective serum concentrations.
- Exposure to high concentrations for a prolonged period may cause renal impairment or ototoxicity.
- Patients with impaired renal function should be monitored closely while on gentamicin therapy because nephrotoxicity caused by gentamicin may be difficult to distinguish from the symptoms of underlying renal disease. In addition, patients with compromised renal function eliminate gentamicin more slowly than patients with normal renal function.
Performing Laboratory
CRMC Laboratory
CCMC Laboratory
