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Helicobacter pylori, IgG
Test CodeHPSEG
Alias/See Also
H Pylori IgG, H. Pylori IgG AB
CPT Codes
86677
Preferred Specimen
GOLD (SST)
Other Acceptable Specimens
Red
Only Serum is acceptable
Only Serum is acceptable
Specimen Stability
- Samples are stable at room temperature for up to 24 hours.
- 3 days at 2-8°C; otherwise aliquoted samples may stored frozen (-20°C or below).
- If samples are stored frozen, mix thawed samples well before testing. Samples may be frozen-thawed 5 times. Self-defrosting freezers are not recommended for sample storage.
Methodology
Indirect Chemiluminescent Immunassay (CLIA)
Setup Schedule
24x7
Limitations
Range: 0.01 to 9.4 IV
Reference Range
5/19/2026
H. Pylori AB IgG:
CUTOFF POINTS for H. Pylori Ab, IgG
0.79 or less IV ...... Negative
0.80 - 0.89 IV ....... Equivocal
0.90 IV or greater .. Positive
Negative result: Indicates that the patient has not been infected but does not always rule out acute H. Pylori infection.
Equivocal result: Recommend retesting patient in one to two weeks.
Positive result: Indicates the presence of detectable IgG antibody to H. Pylori.
H. Pylori AB IgG:
CUTOFF POINTS for H. Pylori Ab, IgG
0.79 or less IV ...... Negative
0.80 - 0.89 IV ....... Equivocal
0.90 IV or greater .. Positive
Negative result: Indicates that the patient has not been infected but does not always rule out acute H. Pylori infection.
Equivocal result: Recommend retesting patient in one to two weeks.
Positive result: Indicates the presence of detectable IgG antibody to H. Pylori.
Clinical Significance
Helicobacter pylori (H. pylori) is a gram-negative, helix-shaped, bacterium found in the human stomach which is transmitted through oral-oral and/or fecal-oral route. It is the causative agent of chronic gastritis (nflammation of the stomach lining), duodenal ulcer, stomach ulcer, and is associated with an increased risk of stomach cancer. H. pylori uses its flagella to actively burrow through the mucus reaching the stomach’s epithelial cell layer and urease to degrade urea into carbon dioxide and ammonia, helping to neutralize the gastric acid present in the stomach which enable H. pylori capable of colonizing the harsh acidic environment of the stomach. Once colonization of the stomach is established, H. pylori will likely persist indefinitely unless antimicrobial intervention is prescribed. Several methods are used to diagnose H. pylori infection including gastric biopsy, UBT (urea breath test), stool antigen, and serological testing. Serological testing is the first choice for the detection of H. pylori infection because it is easy to perform compared to the more invasive diagnostic tests. However, a positive serologic test does not confirm the active disease. It indicates the presence of H. pylori antibodies which confirms both a possibility for past infections or potential current infections.
Performing Laboratory
CRMC Chemistry Laboratory
