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Transferrin
Test CodeCPT Codes
84466
Preferred Specimen
Other Acceptable Specimens
EDTA Lav
Instructions
Specimen Stability
Setup Schedule
Reference Range
Male: 215-365 mg/dL
Clinical Significance
Iron in plasma is bound to the transport protein transferrin. Transferrin is responsible for 50% to 70% of the iron binding capacity of serum. Transferrin has two iron-binding sites and is largely, but not exclusively, synthesized by the liver.
Transferrin levels rise with iron deficiency and fall in cases of iron overload. Increase in transferrin is seen in iron deficiency anemia. It may also be increased late in pregnancy and in women on oral contraceptives. It is decreased in conditions associated with increased protein loss, such as nephrotic syndrome, chronic renal failure, severe burns, and protein-deficiency states and in severe liver disease. Transferrin is a negative acute-phase protein and will be decreased during any inflammatory state or severe illness.
Performing Laboratory
CRMC Laboratory
CCMC Laboratory
CCI Laboratory