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Hepatitis B Virus Surface Antibody (HBsAb)
MessageIncluded in Hepatitis Panel, Chronic (HEPCP)
Test Code
CPT Codes
86706
Preferred Specimen
Other Acceptable Specimens
Instructions
Specimen Stability
- Store primary tube samples at 2 – 80 C for up to 7 days.
- Serum and EDTA plasma samples maintained at room temperature up to 7 days and heparinized plasma specimens maintained at room temperature for up to 3 days demonstrates no qualitative differences.
- Freeze samples, devoid of red blood cells, at or below -200 C for longer storage. Frozen samples must be stored in a non-frost free freezer. Specimens may be frozen and thawed up to 4 times. Thoroughly mix thawed specimens, and centrifuge to remove particulates. Transfer the supernatant to a clean tube prior to testing.
Setup Schedule
Reference Range
Anti HBS >= 10mIU/mL is considered to indicate protective immunity to HBV infection.
Clinical Significance
Hepatitis B virus (HBV) is endemic throughout the world and is the major cause of liver disease. HBV is transmitted sexually and through direct contact with blood and body fluids. The average incubation period for HBV infection is 6 to 8 weeks (range 1 to 6 months). Common clinical symptoms include malaise, fever, gastroenteritis, and icterus. HBV infection can result in typical icteric hepatitis, subclinical anicteric hepatitis, fulminant hepatitis, or chronic or persistent hepatitis.
The presence of antibody to hepatitis B surface antigen (anti-HBs) is used to determine immune status to HBV or disease progression in individuals infected with HBV. An increase in anti-HBs levels, together with a loss of detectable circulating hepatitis B surface antigen (HBsAg), denotes convalescence in hepatitis B infections. Furthermore, anti-HBs levels can be measured to determine if vaccination is needed, or following a vaccination regimen, to determine if protective immunity has been achieved.
Performing Laboratory
CRMC Laboratory
