Creatine Kinase Fraction, CK-MB FRACTION

Test Code

CPKMB

Alias/See Also

CKMB, CKMB FRACTION

CPT Codes
82553, 82550

Includes

CPK: Creatine Kinase
CKMB: CK-MB Fraction
CKMBC: CPK-MB%Index

Preferred Specimen

Light GREEN (PST)

Other Acceptable Specimens

Serum (Red) or Gold (SST) or Orange (OJ) or Tiger Top Serum

Instructions

Includes total CK

Specimen Stability

If samples cannot be assayed within 8 hours, refrigerate samples at 2-8ºC.
If the assay cannot be completed within 48 hours, or for the shipment of samples, freeze at -20ºC or colder. Samples can only be thawed once. Samples should not be thawed in a water bath. Mix gently by inversion and centrifuge after thawing prior to sample analysis.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Avoid assaying lipemic, icteric, or hemolyzed samples.

Setup Schedule

24x7

Reference Range

CPK CRMC and CCMC:
Female: 26-140 U/L Male: 38-174
CPK FHSH:
Female: 26-192 U/L Male: 39-308

CKMB: 0-4.9 ng/mL
CKMBC (MB% Index): 0.0-2.4%

Clinical Significance

CK-MB isoenzyme is located primarily in the myocardium, representing 20% of the total CK activity. Amounts greater than 5% can be found in the prostate, spleen or skeletal muscle, where quantities of CK-MB may change as a function of the muscle type. After an acute myocardial infarction (AMI), CK-MB appears in the circulation, reflecting damage to the myocardium. CK-MB rises rapidly to peak levels (within 12 hours) then declines to normal levels (36-72 hours). This pattern of rising and falling CK-MB values, along with evolutionary changes in the ECG and a history of chest pain, is generally considered diagnostic of AMI. Measurements of CK-MB can also aid in the non-invasive assessment of the efficacy of myocardial reperfusion following thrombolytic therapy. Elevated levels of CK-MB are also associated with skeletal muscle trauma, but don't have the rise and fall characteristics of CK-MB level in AMI.

Performing Laboratory
CRMC Laboratory (CPK, CKMB)
CCMC Laboratory (CPK)
FHSH Laboratory (CPK)

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.