High Sensitivity Troponin I Assay

Message

Test Code

HSTNI

Alias/See Also

Troponin I, High Sensitivity Troponin I, High Sensitive TNI, HSTNI, High Sensitivity Troponin, High Sensitivity TNI

CPT Codes
84484

Preferred Specimen

Serum (ORANGE Vacutainer)

Minimum Volume

0.5 ml

Other Acceptable Specimens

Serum (Gold)
Plasma ( LT Green PST-Lithium Heparin)

Specimen Stability

Physically separate (centrifuge) serum or plasma from contact with cells as soon as possible.
Stability:
- Up to Eight (8) Hours: Store samples tightly stoppered at room temperatures (15 to 30°C).
- Up to Forty-Eight (48) Hours: Store specimens tightly stoppered at refrigerated temperatures (2 to 8°C).
- Up to 180 Days: Store Specimens tightly stoppered at Freezer temperatures (-20°C or colder). Thaw samples only once.

Methodology
Beckman hsTNI Reagent

Setup Schedule

24x7

Reference Range

Gender Specific Reference Range:

Female: <15 ng/L
Male: <20 ng/L
Nonbinary/Unknown: <20 ng/L

Critical Value: >100 ng/L

HSTNI Delta reference Range: <= 4 ng/L
Note: Delta Calculation will only be resulted if there is a prior HSTNI in the past 7 hours.

Analytical Measurement Range (AMR): 2 to 270,270 ng/L

Clinical Significance

High Sensitivity Troponin I (HSTNI) assays are used to measure the levels of cardiac Troponin I in the blood, which is a protein released when the heart muscle is damaged. These tests are approximately 1000 more sensitive than previous Troponin I (TNI) assays. This allows for the detection of even tiny amounts of Troponin I that may indicate heart conditions such as heart attacks. The high sensitivity of this assay enables earlier and more accurate detection of heart issues which can significantly impact patient management and outcomes.

Patient Management/Treatment Pathways:
Due to this assay change, there are two new dynamic Patient Management/Treatment Pathways available in Epic to help providers manage patient care with this assay and results. These pathways can be accessed in a patient chart using the Pathways Tab in Epic (see AgileMD Pathways Tip Sheet).

Note: Pathways are currently in Draft form and order links will be live 5/1/25.
Pathway Names:

Inpatient Chest Pain Evaluation (High Sensitivity Troponin)ED Chest Pain Evaluation (High Sensitivity Troponin)

Static versions of the pathways can also be accessed through:

CMC Laboratory Directory of Service: Provides Links to the Assay Information and the Pathways.

Performing Laboratory
CRMC Laboratory
CCMC Laboratory
FHSH Laboratory

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.