Cardiolipin Antibodies  (IgA, IgG, IgM)

Test Code

CPT Codes
86147 (x3)

Preferred Specimen
1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume
0.5 mL

Other Acceptable Specimens

Transport Container
Plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Immunoassay (IA)

Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day

Reference Range

Cardiolipin Antibody (IgA)
≤11 APL Negative
12-20 APL Indeterminate
21-80 APL Low to medium positive
>80 APL High positive

Cardiolipin Antibody (IgG)
≤14 GPL Negative
15-20 GPL Indeterminate
21-80 GPL Low to medium positive
>80 GPL High positive

Cardiolipin Antibody (IgM)
≤12 MPL Negative
13-20 MPL Indeterminate
21-80 MPL Low to medium positive
>80 MPL High positive

Clinical Significance
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.