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Oxycodone and Metabolite, Quantitative, Serum
Test CodeOXYCO
CPT Codes
80365
Includes
Oxycodone and Oxymorphone
Preferred Specimen
5 mL serum collected in a red-top tube (no gel)
Minimum Volume
3 mL
Instructions
Do not use serum separator tubes.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 7 days
Refrigerated: 7 days
Frozen: 7 days
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Wed, Fri; Report available: 3-5 days
Clinical Significance
For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy. Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg respectively. Oxymorphone is a minor but active metabolite of oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.
Performing Laboratory
Quest Diagnostics Nichols Institute Valencia
27027 Tourney Road
Valencia, CA 91355-5386