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Bladder Cancer, FISH
MessageOrder Uncoded, Miscellaneous with Quest test number 10107.
Test Code
10107
Alias/See Also
Urovysion; Urovysion FISH; FHURO; 10107
CPT Codes
88121
Preferred Specimen
Collection Kit for Urine Cytology or UroVysion FISH Testing
Minimum Volume
33 mL
Other Acceptable Specimens
None
Instructions
Urine (preferred): A urine preservative transport kit, with handling instructions, is available upon request. Perform urine collection (50 mL) at the physician's office or Patient Service Center (PSC) in a sterile 100 mL urine specimen container. Mix voided urine with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix urine with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (DO NOT FREEZE). Under no circumstances should bladder-washing specimens be stored or shipped at temperatures at or above 37°C.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject. Do not freeze.
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (DO NOT FREEZE). Under no circumstances should bladder-washing specimens be stored or shipped at temperatures at or above 37°C.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject. Do not freeze.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions
Refrigerated: See instructions
Frozen: See instructions
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
The analytical performance characteristics of this assay have been determined by Quest Diagnostics Nichols Institute. The modifications have not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 4 days after receipt at the performing laboratory. Add two (2) days for transport.
Reference Range
See Laboratory Report
Clinical Significance
UroVysion® FISH, detects aneuploidy of chromosomes 3,7,17 and loss of 9p21 locus. Useful for monitoring bladder cancer and in the initial diagnosis of bladder cancer in patients with hematuria.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: August 31, 2023
