4K Prostate Score, Serum

Note:  Test will not be performed with out DRE, Digital Rectal Exam, result.  DRE cannot be performed within 96 hours before sample collection, but can be performed after phlebotomy or within the 12 months before testing.

Biopsy history must be provided at time of order.  

Test Code

Alias/See Also
Kallikrein score, 4Kscore, 4K prostate screen

CPT Codes

PSA Total, PSA Free, % Free PSA, 4K Score

Preferred Specimen
1 Gold SST tube

Patient Preparation
Digital Rerctal Exam (DRE) result must be provided.  Do not perform DRE within 96 hours before sample collection.

Minimum Volume
3 mL

Transfer 4mL serum to a standard transport vial.  Separate specimens must be submitted when multiple tests are ordered.

Transport Container
Transport tube

Transport Temperature

Specimen Stability
15-30C unacceptable
2-8C up to 72 hours
-20C up to 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Frozen Serum Separator Tubes (SST)

Electrochemiluminescence Immunoassay (ECLIA)

FDA Status

Report Available
2 days

The 4K Score test is limited to patients age 45 and over.

Reference Range
By report

Clinical Significance
High Grade (Gleason 7+) Prostate Cancer Risk Evaluation

Performed By
Alverno Laboratories

Performing Laboratory
Bioreference Laboratories
Test code:  J148

Last Updated: January 11, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.