Prostate Health Index Reflex, Serum

Message

Calculation of prostate health index (phi) as a part of a reflex test when PDA concentrations are between 4 and 10 ng/mL.

Test Code

PHIR

Alias/See Also

PHI11

CPT Codes
84153, 84154 (if reflexed), 86316 (if reflexed)

Includes

Total PSA, Free PSA (if reflexed) and -2 ProPSA (if reflexed)

Preferred Specimen

1 Red tube (no gel)

Patient Preparation
Specimens for testing should be collected prior to prostate manipulations such as digital rectal examination (DRE), prostatic massage, transrectal ultrasound (TRUS) and prostatic biopsy. A 6-week waiting period between needle biopsy and specimen collection is recommended. Specimens should not be collected from patients receiving therapy with high biotin (vitamin B7) doses until at least 8 hours following the last dose.

Minimum Volume

0.75 mL

Instructions

Centrifuge, aliquot serum into plastic vial, and refrigerate serum within 3 hours of collection. Freeze sample within 24 hours of collection and send frozen.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

-20C up to 150 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, gross icterus

Methodology
Immunoenzymatic Assay

FDA Status
Approved

Setup Schedule

Mon - Sat

Report Available

1-3 days

Reference Range

Females: Not applicable
Male ranges are on an attached table

Clinical Significance

Aiding in distinguishing prostate cancer from benign prostate conditions in men with prostate-specific antigen (PSA) concentrations in the 4 to 10 ng/mL range and digital rectal examination (DRE) findings that are not suspicious for cancer.

Performed By
Alverno Laboratories

Performing Laboratory
Mayo Clinic Laboratories
Test Code: PHI11

Last Updated: May 16, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.