Apolipoprotein E Genotyping, Blood

APOE genotypting has been used to assess susceptibility for Alzheimer disease.  However, the use of APOE analysis for predictive testing for Alzheimer disease is not currently recommended by the American College of Medical Genetics due to limited clinical utility and poor predictive value.

Test Code

Alias/See Also
APOE, Dislipidemia, Dysbetalipoproteinemia, Dyslipidemia, Dyslipoproteinemia, Alzheimer disease, Dementia, Frederickson Type III, Hyperlipidemia Type III, Type III hyperlipoproteinemia

CPT Codes

Physician Attestation of Informed Consent

Result Summary, Result, Interpretation, Reason for Referral, Specimen, Source, Released By

Preferred Specimen
3 mL Lavender (EDTA) whole blood

Minimum Volume
1 mL

Other Acceptable Specimens
Yellow top (ACD), Sodium Heparin whole blood, Sodium Citrate whole blood

Invert specimen several time to mix blood.  Send whole blood specimen in original tube.  Do not aliquot.

Transport Temperature
Room temperature

Specimen Stability
Specimen preferred to arrive within 96 hours of collection

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

PCR including Restriction Digest

FDA Status

Setup Schedule

Report Available
9-10 days

Reference Range
An interpretive report will be provided.

Clinical Significance
Determining the specific apolipoprotein E (APOE) genotypes in patients with type III hyperlipoproteinemia.

Performed By
Alverno Laboratories

Performing Laboratory
Mayo Clinic Laboratories
Test Code:  APOEG

Last Updated: May 16, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.