CELIAC DISEASE PANEL, (Greater than 2 years old)

Message

This test should be ordered for patients two years and greater.

Test Code

CELAD

CPT Codes
82784, 86364 plus 86231 (if IgA is normal) or 86258 (if IgA is low)

Includes

Includes: Total IgA, Tissue Transglutaminase IgA, Endomysial IgA antibody, and Pathologist interpretation. NOTE: If the Total IgA result is low, Tissue Transglutaminase IgG and Deamidated Gliadin IgG will be performed in place of Tissue Transglutaminase IgA and Endomysial IgA antibody.

Preferred Specimen

1 Gold tube (gel separator)

Minimum Volume

1 mL

Other Acceptable Specimens

None

Instructions

Centrifuge for complete separation of serum and red cells. Separate and refrigerate or freeze within two (2) hours of collection time.

Transport Temperature

Refrigerate or freeze.

Specimen Stability

2-8°C up to 2 days; otherwise freeze at -20° or lower

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolyzed or lipemic samples

Methodology
ELISA

Setup Schedule

T, Th

Report Available

Within 48 hours of day tested at the performing laboratory.

Reference Range

IgA levels are normal and both TTG IgA and EMA IgA levels are within normal limits.

In low risk patients (<5% disease probability), celiac disease is effectively excluded.
In high risk patients (>5% disease probability), small bowel biopsy is recommended.

If histology is negative, celiac disease is excluded. If histology is positive, HLADQ2 and DQ8 testing is recommended.

Note: consider other causes for villous atrophy.

Clinical Significance

This panel of serologic studies facilitates the diagnosis of celiac disease and follows the recommendations of the American Gastroenterological Association.

Performed By
Alverno Laboratories

Performing Laboratory
Alverno Central Lab
NIM1 (Immunology, Manual)

Last Updated: January 23, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.