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ELECTROPHORESIS, HEMOGLOBIN
Message***This test includes a Pathologist Interpretation***
Test Code
HGBP2
Alias/See Also
Evaluation, Hemoglobin; Fetal Hemoglobin (Hemoglobin F); Hb; Hb ELP; Hb IEF; Hemoglobin Evaluation; Hemoglobin Fractionation; Hemoglobinopathy Fractionation Profile; Hgb; Sickle Cell Anemia Screen; Sickle Cell Disease; Sickle Cell Screen
CPT Codes
83020
Includes
Includes: Hgb A, F, S,A2, C, Other 1, Other 2, A2 Variant, Interpretation and Sickledex on positive Hgb S
If additional testing for variant hemoglobin is needed, please order Hemoglobinopthay Evaluation to provide a difinitive diagnosis.
This test should not be used for patients with a known diagnosis.
If additional testing for variant hemoglobin is needed, please order Hemoglobinopthay Evaluation to provide a difinitive diagnosis.
This test should not be used for patients with a known diagnosis.
Preferred Specimen
1 Lavender tube (EDTA)
Minimum Volume
1 mL
Instructions
Do not centrifuge
Transport Temperature
Refrigerate
Specimen Stability
2-8°C up to 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed
Methodology
Capillary Electrophoresis
Setup Schedule
M, T, W, Th, F
Report Available
Within 24 hours of the next testing day after receipt at the performing laboratory. Additional time needed if variant testing is required. Please note: this test requires a Pathologist interpretation of results which may delay the final report.
Reference Range
Normal hemoglobin types include:
- Hemoglobin A (Hb A): makes up about 95%-98% of hemoglobin found in adults.
- Hemoglobin A2 (Hb A2 ): makes up about 2%-3% of hemoglobin found in adults.
- Hemoglobin F (Hb F, fetal hemoglobin): makes up to 1%-2% of hemoglobin found in adults. Hb F is the primary hemoglobin produced by the fetus during pregnancy. Production of Hb F falls shortly after birth and reaches adult level within 1-2 years.
Clinical Significance
Hemoglobin is the iron-containing protein compound within red blood cells that carries oxygen throughout the body. It is made up of heme, which is the iron-containing portion, and globin chains, which are proteins. Red blood cells containing abnormal hemoglobin may not carry oxygen efficiently and may have a shorter life span in the body.
Genetic changes in the globin genes cause alterations in the globin protein, resulting in a hemoglobin mutations such as hemoglobin S or hemoglobin C, among others. Hb S causes sickle cell disease and Hb C causes hemolytic anemia.
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Central Lab
NCH4 (Chemistry, Sebia Electrophoresis)
Additional Information
Hemoglobinopathy Evaluation
Last Updated: April 25, 2024
