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MSI for CHECKPOINT THERAPY
Test CodeMSICP
CPT Codes
81301; 88381
Includes
- This assay detects instability at genotypes ACVr2; BTBD7; DIDO1; MRE11; RYR3; SEC31 and SULF2
- Includes Pathologist interpretation
- Mutation Detections:
- ACVR2A- 2q22.3-q23.1
- BTBD7 - 14q32.12
- DIDO1 - 20q13.33
- MRE11 - 11q21
- RYR3 - 15q13.3-q14
- SEC31A - 4q21.22
- SULF2 - 20q13.12
Preferred Specimen
Please send 2-5 slides (≥50mm tissue area) or paraffin block and 1 H&E slide with the area of invasive tumor circled. Send tissue block to Molecular in a red pathology interoffice envelope. AP request form must be included with order.
Other Acceptable Specimens
None
Transport Temperature
Room temperature
Specimen Stability
Room temperature - cut slides are stable 60 days. Paraffin blocks are stored for 10 years.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
- Less than 20% tumor cells
- Samples sent frozen
- Decalcified specimens
Methodology
Real Time Polymerase Chain Reaction (PCR)
Setup Schedule
No set day
Report Available
Report available within 3 days of receipt at the performing laboratory.
Reference Range
Microsatellite Stable / Intact DNA mismatch repair detected (MSS/MSI-L)
Clinical Significance
Useful for determining potential eligibility for Check Point Therapy by identifying microsatellite instability-high (MSI-H) cancers.
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Central Lab
NMB18 (Molecular Biology, Idylla)
Last Updated: June 8, 2023