A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Nicotine and Cotinine, Urine
Test CodeURNIC
Alias/See Also
90646
CPT Codes
80323
Preferred Specimen
1 mL random urine, collected in a plastic, screw-capped vial or a plastic, leak-proof urine container
Minimum Volume
0.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat evening; Report available: 3 days after receipt at the performing laboratory. Add two (2) days for transport.
Reference Range
Nicotine, Urine
Cotinine, Urine
Smoker | 200-700 ng/mL |
Nonsmoker | ≤17 ng/mL |
Cotinine, Urine
Smoker | 300-1300 ng/mL |
Nonsmoker | ≤20 ng/mL |
Clinical Significance
This assay is used for the detection of nicotine and cotinine in urine to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for several days after cessation of tobacco exposure.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |
Last Updated: June 22, 2023