Zinc Protoporphyrin (ZPP)

Test Code

ZPP

Alias/See Also

948

CPT Codes
84202

Preferred Specimen

2 mL whole blood collected in an EDTA (tan-top) tube

Minimum Volume

0.5 mL • Pediatric specimen: 0.2 mL

Other Acceptable Specimens

Whole blood collected in: EDTA (royal blue-top) tube, sodium heparin (royal blue-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube

Instructions

Use a lead-free tube if blood lead is also requested

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 10 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Received frozen • Clotted • EDTA (lavender-top) tube

Methodology
Hematofluorometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 1-2 days after receipt at the performing laboratory. Add two (2) days for transport.

Limitations

Aluminum and anemia of chronic disease may cause elevated results.

Reference Range

Industrial Exposure

<100 mcg/dL

(Refer to current OSHA regulation for exposure criteria.)

Clinical Significance

Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: June 22, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.