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Chromosome Analysis, POC Tissue

Test Code
CHMPC


Alias/See Also
14593


CPT Codes
88233, 88262

Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.


Preferred Specimen
5x5 mm tissue collected in a sterile container in Hanks', Ringer's solution, or culture medium with antibiotics


Minimum Volume
2x3 mm tissue


Other Acceptable Specimens
Fetal tissue in sterile saline solution submitted in a sterile leak-proof container • Cultured cells collected in T-25 flasks with culture medium


Instructions

Patient clinical history/reason for referral required with test order.

Fetal tissue sample minimum of 2x3 mm collected in a sterile container with Hanks', Ringer's solution, culture medium with antibiotics, or saline solution. Transport media should be refrigerated before use, but can be shipped at room temperature.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject



Transport Temperature
Room temperature


Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable


Methodology
Karyotype • Microscopy • Tissue Culture

Setup Schedule
Set up: Daily; Report available: 15 days after receipt at the performing laboratory. Add two (2) days for transport.


Reference Range
See Laboratory Report


Clinical Significance
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153


Last Updated: May 12, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.