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Chromosome Analysis, POC Tissue
Test CodeCHMPC
Alias/See Also
14593
CPT Codes
88233, 88262
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
5x5 mm tissue collected in a sterile container in Hanks', Ringer's solution, or culture medium with antibiotics
Minimum Volume
2x3 mm tissue
Other Acceptable Specimens
Fetal tissue in sterile saline solution submitted in a sterile leak-proof container • Cultured cells collected in T-25 flasks with culture medium
Instructions
Patient clinical history/reason for referral required with test order.
Fetal tissue sample minimum of 2x3 mm collected in a sterile container with Hanks', Ringer's solution, culture medium with antibiotics, or saline solution. Transport media should be refrigerated before use, but can be shipped at room temperature.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Karyotype • Microscopy • Tissue Culture
Setup Schedule
Set up: Daily; Report available: 15 days after receipt at the performing laboratory. Add two (2) days for transport.
Reference Range
See Laboratory Report
Clinical Significance
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: May 12, 2023