A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Chromosomal Microarray, POC, ClariSure® Oligo-SNP
Test CodeMCPOC
Alias/See Also
90929
CPT Codes
81229
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
5x5 mm fetal tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics
Minimum Volume
2x3 mm tissue
Other Acceptable Specimens
5x5 mm fetal tissue in saline solution submitted in a sterile leak-proof container • Cultured cells collected in two T25 flasks
Instructions
Clinical history/reason for referral is required with test order.
Fetal tissue sample minimum of 2x3 mm collected in a sterile container with Hanks', Ringer's solution, culture medium with antibiotics, or saline solution or cultured cells from tissue specimen.
Transport media should be refrigerated before use, but can be shipped at room temperature.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Oligo-SNP Array
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 12 days after receipt at the performing laboratory. Add two (2) days for transport.
Reference Range
See Laboratory Report
Clinical Significance
Chromosomal microarray (CMA) detects aneuploidies, deletions and duplications below the resolution of chromosome analysis (karyotyping), and long continuous regions of homozygosity. Approximately 50% of first trimester pregnancy losses are due to chromosome abnormalities. While chromosome analysis on products of conception has an increased failure rate, chromosomal microarray is a DNA-based analysis, which rarely has assay failures.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: May 5, 2023