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Hexagonal Phase Confirmation
Test CodeHEXPC
Alias/See Also
36573
CPT Codes
85598
Preferred Specimen
1 mL frozen platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
0.5 mL
Instructions
Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.
Transport Container
Plastic vial
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Clot Detection
Setup Schedule
Set up: Mon-Fri; Report available: 1-4 days after receipt at the performing laboratory. Add two (2) days for transport.
Reference Range
Negative
Clinical Significance
The hexagonal phase confirm assay is a specific test for the detection of Lupus anticoagulants (LA). However, as LA reflect a heterogeneous group of antibodies, international guidelines require a multi-test approach to LA detection. For a comprehensive evaluation, refer to Lupus anticoagulant Comprehensive Evaluation.
Note: Target-specific anticoagulant therapy (anti-Xa medications, direct thrombin inhibitors) may cause false positive results.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: May 4, 2023