Test Code

Alias/See Also

CPT Codes

Preferred Specimen
1 mL whole blood collected in a fluoride oxalate (gray-top) tube

Patient Preparation
Do not use alcohol solutions as skin preparation for drawing specimens. Use non-alcohol solutions such as Betadine® or Zephiran®. Keep transport container tightly sealed.

Minimum Volume
0.5 mL

Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube • Serum collected in a red-top tube (no gel) • Whole blood collected in a potassium oxalate (gray-top) tube

Do not open. Keep specimen tightly capped. Prevent exposure to atmosphere.

Transport Container
Plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days


FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Daily; Report available: 1 day after receipt at the performing laboratory. Add two (2) days for transport.

Patients with diabetes who may also have lactic acidosis may have false negatives or falsely weak reactions. With these patients a beta-hydroxybutyrate measurement may be preferred. High concentrations of levodopa may produce false positives. Ketogenic or low/no-carb diets, often instituted for pediatric epilepsy, may also produce false positive results.

Reference Range
None detected

Clinical Significance
Excessive formation of ketone bodies (acetone) results in increased blood levels (ketonemia) and increased excretion in the urine (ketonuria). This condition is associated with a decreased availability of carbohydrates, such as dieting or decreased use of carbohydrates. Diabetes and alcohol consumption are common causes of ketoacidosis. Acetone is one ketone body formed from acetoacetate. Ingestion of isopropyl alcohol also leads to the formation of acetone.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: August 4, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.