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Urine Methadone Screen
Test CodeUMETHD
Alias/See Also
Methadose, Dolophine, METH
Preferred Specimen
15 mL urine (2 mL minimum)
Instructions
Freshly voided urine specimens should be used for testing. No additives or preservatives are needed. Adulteration of the urine specimen may cause erroneous results. If adulteration is suspected, obtain a fresh specimen. Deliver specimen to laboratory immediately.
Transport Container
Urine collection cup
Specimen Stability
Room temperature: 4 hours, Refrigerated: 24 hours, Freeze if storage for longer than 24 hours is required.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Do NOT use boric acid as a preservative.
Limitations
This is a screening assay. Methadone is detected in concentration at or above 300 ng/mL
Reference Range
None detected
Clinical Significance
Methadone is a synthetic narcotic/analgesic drug that is administered orally or intravenously.
Medically assisted withdrawal from opioids is usually accomplished using methadone. Methadone is frequently used in maintenance programs as a substitute for heroin or other abused opioids, while allowing the subject to successfully participate in drug rehabilitation. Patients are able to function well on methadone and perform complex tasks competently.
Methadone is metabolized in the liver. The kidneys become a major route of methadone excretion at doses exceeding 50 mg/dL. Urine levels in methadone maintenance patients range from 1 to 5 μg/mL 24 hours after methadone dose.
Medically assisted withdrawal from opioids is usually accomplished using methadone. Methadone is frequently used in maintenance programs as a substitute for heroin or other abused opioids, while allowing the subject to successfully participate in drug rehabilitation. Patients are able to function well on methadone and perform complex tasks competently.
Methadone is metabolized in the liver. The kidneys become a major route of methadone excretion at doses exceeding 50 mg/dL. Urine levels in methadone maintenance patients range from 1 to 5 μg/mL 24 hours after methadone dose.
