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Urine Buprenorphine Screen
Test CodeUBUP
Physician Attestation of Informed Consent
BUP, Subutex
Preferred Specimen
15 mL urine (2 mL minimum)
Instructions
Freshly voided urine specimens should be used for testing. No additives or preservatives are needed. Adulteration of the urine specimen may cause erroneous results. If adulteration is suspected, obtain a fresh specimen. Deliver specimen to laboratory immediately.
Transport Container
Urine collection cup
Specimen Stability
Room temperature: 5 days, Refrigerated: 5 days, Freeze if storage for longer than 5 days is required
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Do NOT use boric acid as a preservative.
Limitations
This is a screening assay. Buprenorphine is detected in concentration at or above 5 ng/mL
Reference Range
None detected
Clinical Significance
Buprenorphine is a semi-synthetic opioid analgesic derived from thebaine, a component of the opium poppy Papaver somniferum. Buprenorphine structurally resembles morphine, but has both antagonist and agonist properties. Buprenorphine is a schedule III drug. The Food and Drug Administration (FDA) has approved the use of Suboxone, which contains buprenorphine for treatment of opiate dependency in the US. Under the US Drug Abuse Treatment Act of 2000 (DATA) buprenorphine can be prescribed in a physician’s office for treatment of opiate dependency.
It has been shown that buprenorphine has abuse potential and may itself cause dependency. It produces typical opioid effects and side effects such as euphoria and respiratory depression.
Buprenorphine is metabolized in the human liver primarily by N-dealkylation to pharmacologically active norbuprenorphine, which along with the parent compound is conjugated to form buprenorphine glucuronide and norbuprenorphine glucuronide.
It has been shown that buprenorphine has abuse potential and may itself cause dependency. It produces typical opioid effects and side effects such as euphoria and respiratory depression.
Buprenorphine is metabolized in the human liver primarily by N-dealkylation to pharmacologically active norbuprenorphine, which along with the parent compound is conjugated to form buprenorphine glucuronide and norbuprenorphine glucuronide.
