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Myoglobin
Test CodeMYOGL
Alias/See Also
Myoglobin Quant, MYO
Preferred Specimen
1.0 mL plasma (0.5mL minimum)
Transport Container
PST (light green top). Red top and SST also acceptable
Specimen Stability
Room temperature: 8 hours, Refrigerated: 7 days, Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed specimens are unacceptable
Report Available
Same day
Reference Range
10 - 92 ng/mL
Clinical Significance
Myoglobin is a heme protein found in both cardiac and skeletal muscle and is released in serum when damage occurs to the cardiac or skeletal muscle cells. In the absence of skeletal muscle trauma or other factors associated with a non-cardiac related increase in circulating myoglobin, myoglobin levels have been used as an early marker for measurement of MI. Following myocardial necrosis associated with myocardial infarction (MI), myoglobin is one of the first markers to rise above normal levels, increasing measurably above baseline within 1-3 hours post infarct, peaking at 6-12 hours and returning to baseline within 24-36 hours. A number of reports suggest the measurement of myoglobin as a diagnostic aid in risk stratification for myocardial infarction with negative predictive values of up to 100% reported at certain time periods after onset of symptoms.
The American College of Cardiology/American Heart Association (ACC/AHA) practice guidelines recommend the utilization of an early marker of cardiac injury, like myoglobin, for patients who present within 6 hours of onset of symptoms.
The American College of Cardiology/American Heart Association (ACC/AHA) practice guidelines recommend the utilization of an early marker of cardiac injury, like myoglobin, for patients who present within 6 hours of onset of symptoms.
