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Sickle Cell Screen
Test CodeBSKL
Alias/See Also
Sickle test, SICKLEDEX, Sickle Cell Anemia Screen, Sickle Cell Hemoglobin Screen, Hemoglobin S Solubility, Sickle Cell Solubility Test
Preferred Specimen
1.0 mL whole blood (0.5 mL minimum)
Transport Container
EDTA (lavender/purple top). Heparin (green top) is acceptable.
Specimen Stability
Room temperature: 1 day, Refrigerated: 45 days, Frozen: unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimens are unacceptable.
Limitations
False positives may occur in patients with erythrocytosis, hyperglobulinemia, extreme leukocytosis, or hyperlipidemia.
False positive or false negative results may occur in patients with severe anemia (<15% hemoglobin) or patients with a recent blood transfusion.
False negatives may occur in infants under 6 months of age due to elevated levels of hemoglobin F.
False positive or false negative results may occur in patients with severe anemia (<15% hemoglobin) or patients with a recent blood transfusion.
False negatives may occur in infants under 6 months of age due to elevated levels of hemoglobin F.
Reference Range
Negative
Clinical Significance
This is a qualitative test for the detection of hemoglobin S.
