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Tobramycin, Random
Test CodeTOBR
Alias/See Also
Nebcin, TOBRA
Preferred Specimen
1.0 mL plasma (0.5 mL minimum)
Transport Container
PST (light green top). Red top and SST also acceptable
Specimen Stability
Room temperature: 8 hours, Refrigerated: 3 days, Frozen: 1 month
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed specimens are unacceptable.
Limitations
Aminoglycosides structurally similar to tobramycin (e.g. kanamycin) may significantly cross-react with this method. Therefore, the TOBR method cannot reliably be used for patients receiving these antibiotics separately or in combination with tobramycin.
Reference Range
No established range
Clinical Significance
Tobramycin is an aminoglycoside antibiotic. TOBR test results may be used in the diagnosis and treatment of tobramycin overdose and in monitoring levels of tobramycin to ensure appropriate therapy and minimize ototoxicity and/or nephrotoxicity.