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Osmolality, serum
Test CodeOSMO
Preferred Specimen
1.0 mL serum (0.5 mL minimum)
Transport Container
SST or no additive (red-top)
Specimen Stability
Room temperature: 3 hours; Refrigerated: 3 days; Frozen: 1 week
Reference Range
280-295 mOsm/kg H2O
Clinical Significance
Osmolality determinations are helpful in the clinical management of water and electrolyte disturbances. Serum osmolality studies are useful in the evaluation of hypernatremia and hyponatremia, renal solute retention in acute renal failure and hydration status.