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Amikacin, Random
Test CodeAMKR
Alias/See Also
AMK, Amikin
Preferred Specimen
1.0 mL serum (0.5 mL minimum)
Instructions
Collect anytime ordered by physician. Deliver to the laboratory promptly.
Transport Container
No additive (red-top). SST also acceptable
Specimen Stability
Room temperature: 7 days, Refrigerated: 7 days, Frozen: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Limitations
Patient samples which contain kanamycin will yield falsely elevated values for amikacin.
Reference Range
No established range
Clinical Significance
Monitoring Amikacin concentrations in serum is the most effective means of ensuring adequate therapy. Amikacin concentration in serum correlates better with antibacterial activity than does dosage. A standard dose of amikacin does not always yield a predictable serum level because the drug’s concentration also depends on the patient’s volume of distribution and on drug elimination. These factors are influenced by the mode of administration, the volume of extracellular fluid, renal function, and physiological changes during therapy. Patients with impaired renal function, dialysis patients, burn patients, and neonatal or elderly patients should be monitored closely. Exposure to high concentrations for a prolonged period may cause renal impairment or ototoxicity.
