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Verify Now, Platelet Function
MessagePatients who have been treated with Glycoprotein IIb/IIIa inhibitor drugs should not be tested until platelet function has recovered. This time period is approximately 14 days after discontinuation of drug administration of abciximab (ReoPro) and up to 48 hours for eptifibatide (Integrillin) and tirofiban (Aggrastat). The platelet function recovery times varies among individuals and is longer for patients with renal dysfunction.
Test Code
PRUT
Alias/See Also
P2Y12 Inhibition, VerifyNow, Platelet Inhibition, Plavix Inhibition, PRUTest
Preferred Specimen
Whole blood - collect two 2mL Greiner Bio-one tubes. Refer to Instructions for collection procedure
Minimum Volume
One 2 mL Greiner Bio-One vacuette tube
Instructions
1. Blood samples should be obtained from an extremity free of peripheral venous infusions.
2. Collection of blood sample should be performed with care to avoid contamination by tissue factors.
3. Use a 21 gauge or larger needle. A 21 gauge Butterfly may also be used. First, collect a discard tube (one blue top tube, at least 2 mL).
4. If patient has additional tests ordered, always draw the required tubes for this test first to avoid any contamination.
5. Fill the sample tube to the black line printed half way on the tube. Do not under fill.
6. Collect two tubes per patient.
7. Gently invert the tube at least 5 times to ensure complete mixing of the contents.
NOTE: Specimens must be delivered to the Lab. Do NOT send in the pneumatic tube system.
2. Collection of blood sample should be performed with care to avoid contamination by tissue factors.
3. Use a 21 gauge or larger needle. A 21 gauge Butterfly may also be used. First, collect a discard tube (one blue top tube, at least 2 mL).
4. If patient has additional tests ordered, always draw the required tubes for this test first to avoid any contamination.
5. Fill the sample tube to the black line printed half way on the tube. Do not under fill.
6. Collect two tubes per patient.
7. Gently invert the tube at least 5 times to ensure complete mixing of the contents.
NOTE: Specimens must be delivered to the Lab. Do NOT send in the pneumatic tube system.
Transport Container
Greiner Bio-One partial fill vacuette tube with 3.2% sodium citrate
Specimen Stability
Room temperature: 4 hours, Refrigerated: unacceptable, Frozen: unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted, hemolyzed or under-filled tubes are not acceptable.
Specimens may NOT be sent via the pneumatic tube system.
Specimens may NOT be sent via the pneumatic tube system.
Reference Range
194 - 418 PRU
Clinical Significance
The Verify Now PRUTest is a whole blood test that allows clinicians to measure the actual level of platelet reactivity in patients who have taken P2Y12 inhibitors.
