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Cancer Antigen 125 (Ca-125)
MessagePerformed in Chemistry at BUMCT, BGMC and WyMCC.
Sites not performing in-house, send to Sonora Quest Laboratories, Test Code 3129
Sites not performing in-house, send to Sonora Quest Laboratories, Test Code 3129
Test Code
CA125
Alias/See Also
CA 125
3129
3129
CPT Codes
86304
Preferred Specimen
SQL testing - SST/Gold, Red Serum
WyMCC - SST
BGMC and BUMCT - Green (Li Hep) top tube, plasma
WyMCC - SST
BGMC and BUMCT - Green (Li Hep) top tube, plasma
Instructions
For sites sending to SQL, see link below for specimen details, methodology, setup schedule and reference ranges.
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated 5 days
Frozen 6 months
Frozen 6 months
Clinical Significance
CA 125 belongs to the family of hybridoma defined tumor markers. The values measured are defined by the use of the monoclonal antibody (MAb) OC 125.
Elevated values are sometimes found in various benign gynecological diseases such as ovarian cysts, ovarian metaplasia, endometriosis, uterus myomatosus or cervicitis. Slight elevations of this marker may also occur in early pregnancy and in various benign diseases (e.g. acute and chronic pancreatitis, benign gastrointestinal diseases, renal insufficiency, autoimmune diseases and others). Markedly elevated levels have been found in benign liver diseases such as cirrhosis and hepatitis. Extreme elevations can occur in any kind of ascites due to malignant and benign diseases. Although the highest CA 125 values occur in patients suffering from ovarian carcinoma, clearly elevated values are also observed in malignancies of the endometrium, breast, gastrointestinal tract and various other malignancies.
Elevated values are sometimes found in various benign gynecological diseases such as ovarian cysts, ovarian metaplasia, endometriosis, uterus myomatosus or cervicitis. Slight elevations of this marker may also occur in early pregnancy and in various benign diseases (e.g. acute and chronic pancreatitis, benign gastrointestinal diseases, renal insufficiency, autoimmune diseases and others). Markedly elevated levels have been found in benign liver diseases such as cirrhosis and hepatitis. Extreme elevations can occur in any kind of ascites due to malignant and benign diseases. Although the highest CA 125 values occur in patients suffering from ovarian carcinoma, clearly elevated values are also observed in malignancies of the endometrium, breast, gastrointestinal tract and various other malignancies.
Additional Information
CA 125
