| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Protein, Total
MessagePerformed in Chemistry
Test Code
PROT
Alias/See Also
Total Protein
CPT Codes
84155
Preferred Specimen
Green Top LiHep, Plasma
WyMCC - SST
WyMCC - SST
Other Acceptable Specimens
Lavender Top EDTA, Gold/SST or Red Top
FDA Status
FDA Approved
Setup Schedule
Daily, Sunday through Saturday
Report Available
Less than 4 hours
Clinical Significance
Plasma proteins are synthesized predominately in the liver, plasma cells, lymph nodes, the spleen and in bone marrow. In the course
of disease the total protein concentration and also the percentage represented by individual fractions can significantly deviate from
normal values. Hypoproteinemia can be caused by diseases and disorders such as loss of blood, sprue, nephrotic syndrome, severe
burns, salt retention syndrome and Kwashiorkor (acute protein deficiency).
Hyperproteinemia can be observed in cases of severe dehydration and illnesses such as multiple myeloma. Changes in the relative
percentage of plasma proteins can be due to a change in the percentage of one plasma protein fraction. Often in such cases the
amount of total protein does not change. The A/G ratio is commonly used as an index of the distribution of albumin and globulin
fractions. Marked changes in this ratio can be observed in cirrhosis of the liver, glomerulonephritis, nephrotic syndrome, acute
hepatitis, lupus erythematosus as well as in certain acute and chronic inflammations. Total protein measurements are used in the
diagnosis and treatment of a variety of diseases involving the liver, kidney, or bone marrow, as well as other metabolic or nutritional
disorders
of disease the total protein concentration and also the percentage represented by individual fractions can significantly deviate from
normal values. Hypoproteinemia can be caused by diseases and disorders such as loss of blood, sprue, nephrotic syndrome, severe
burns, salt retention syndrome and Kwashiorkor (acute protein deficiency).
Hyperproteinemia can be observed in cases of severe dehydration and illnesses such as multiple myeloma. Changes in the relative
percentage of plasma proteins can be due to a change in the percentage of one plasma protein fraction. Often in such cases the
amount of total protein does not change. The A/G ratio is commonly used as an index of the distribution of albumin and globulin
fractions. Marked changes in this ratio can be observed in cirrhosis of the liver, glomerulonephritis, nephrotic syndrome, acute
hepatitis, lupus erythematosus as well as in certain acute and chronic inflammations. Total protein measurements are used in the
diagnosis and treatment of a variety of diseases involving the liver, kidney, or bone marrow, as well as other metabolic or nutritional
disorders
