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PROSTAGLANDIN D2 (PG D2), U
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
PGD2
Alias/See Also
PG D2, D2 URINE; FPD2U (Mayo Code)
CPT Codes
84150
Preferred Specimen
10 mL RANDOM URINE, FREEZE IMMEDIATELY
Minimum Volume
5 mL
Instructions
Patient should not be on aspirin, indomethacin, or anti- inflammatory medications, if possible, for at least 48 hours prior to collection of specimen.
Specimen must be frozen within 30 minutes of collection.
Specimen must be frozen within 30 minutes of collection.
Transport Container
PLASTIC CONTAINEER
Transport Temperature
FROZEN
Specimen Stability
Room Temperature: NONE
Refrigerated: NONE
Frozen: 180 DAYS
Refrigerated: NONE
Frozen: 180 DAYS
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
24 HR URINE, PRESERVED URINE
Methodology
DIRECT IMMUNOASSAY (RIA)
Report Available
12 - 14 DAYS
Clinical Significance
Prostaglandins are fatty acids derived from arachidonic acid metabolism. They are closely related to the Thromboxanes and Leukotrienes. Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin D2. Prostaglandin D2 is excreted directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach. Prostaglandin D2 is the major Prostaglandin produced by uterine tissue. Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent. It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti- metastatic effect on many malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin.
Performing Laboratory
Inter Science Institute
944 West Hyde Park
Inglewood, CA 90302
