Chromosomal Microarray, POC, ClariSure® Oligo-SNP

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

POCCHR

Alias/See Also

90929

CPT Codes
81229 <br />

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

5 x 5 tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics

Minimum Volume

2 x 3 mm

Other Acceptable Specimens

Cultured cells collected in flasks • Tissue in sterile saline collected in a sterile screw-cap container

Instructions

Fetal tissue sample minimum 2x3 mm collected in a sterile container in Hanks', Ringer's solution, culture medium with antibiotics, or saline solution or cultured cells from tissue specimen.
⁠⁠⁠⁠⁠⁠⁠
Transport media should be refrigerated before use, but can be shipped at room temperature.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Oligo-SNP Array

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Daily

Report Available

12 days

Clinical Significance

Chromosomal microarray (CMA) detects aneuploidies, deletions and duplications below the resolution of chromosome analysis (karyotyping), and long continuous regions of homozygosity. Approximately 50% of first trimester pregnancy losses are due to chromosome abnormalities. While chromosome analysis on products of conception has an increased failure rate, chromosomal microarray is a DNA-based analysis, which rarely has assay failures.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.