Vasoactive Intestinal Polypeptide (VIP)

Test Code

VASIPL

CPT Codes
84586<br><strong>This test is not available for New York patient testing</strong>

Preferred Specimen

1 mL plasma collected in an EDTA (lavender-top) tube

Patient Preparation
Patient should be fasting 10-12 hours prior to collection of specimen. Patient should not be on any antacid medication or medications that affect intestinal motility for at least 48 hours prior to collection.

Minimum Volume

0.5 mL

Other Acceptable Specimens

Plasma collected in a G.I. preservative tube

Instructions

Centrifuge, separate and freeze plasma as soon as possible. Special G.I. Preservative tubes are available from Inter Science (ISI).

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 6 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly icteric • Gross hemolysis • Grossly lipemic

Methodology
Direct Enzyme Immunoassay/Enzyme Linked Immunosorbent Assay

FDA Status
This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

Setup Schedule

Set up: Varies; Report available: 4-6 business days

Clinical Significance

Vasoactive intestinal polypeptide (VIP) is a 28 amino acid multifunctional peptide that is involved in gastrointestinal, vasodilator, and neuroendocrine functions. VIP is derived from larger pro-molecules that often exhibit the same or greater immunogenicity than the native VIP. It is structurally related to phim, glucagon, secretin, gastric inhibitory polypeptide, corticotropin releasing factor and growth hormone-releasing hormone. VIP stimulates pituitary release of prolactin, growth hormone and ACTH; Stimulates luteinizing hormone-releasing hormone, serotonin, gastric somatostatin, steroids and renin. VIP inhibits the release of gastrin, hypothalamic somatostatin, and histamine. VIP release is stimulated by cholinergic agonists, atropine, serotonin, prostaglandins e1 and d2, and nerve growth factor. VIP actions are inhibited by corticosteroids, dopamine and opiate agonists. Elevated levels of VIP are found in patients with vipomas, hepatic cirrhosis, and the verner-morrison's (watery diarrhea) syndrome. Decreased levels are found in cystic fibrosis.

Performing Laboratory
Inter Science Institute
944 W Hyde Park Blvd
Inglewood, CA 90302

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.