Risperidone and Metabolite

Test Code

RISMET

Alias/See Also

2339

CPT Codes
80299

Includes

Risperidone, OH-Risperidone, Risperidone + OH-Risperidone

Preferred Specimen

3 mL serum collected in a red-top tube (no gel)

Minimum Volume

1.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 31 days
Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tube (SST)

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

9: 00 a. M. Tues, thurs, sat

Report Available

1-4 days

Clinical Significance

Therapeutic drug monitoring for effective therapy. Risperidone is rapidly converted into its hydroxy metabolite in the liver. Peak concentration of risperidone occurs in about 1 hour following oral administration and for 9-hydroxyrisperidone the peak level is reached at 3 hours (17 hours for poor metabolizers). The elimination half-life of risperidone is 3 hours (20 hours for poor metabolizers), and is 21 hours of hydroxyrisperidone (30 hours for poor metabolizers).

Performing Laboratory

Quest Diagnostics Nichols Institute-Valencia

8407 Fallbrook Ave, Suite 100

West Hills, CA 91304-3226

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.