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FISH, Multiple Myeloma, IGH/MAFB, t(14;20)
Test CodeIGHM
Alias/See Also
91387
CPT Codes
88271 (x2), 88275
Preferred Specimen
3 mL bone marrow submitted in culture transport medium
Minimum Volume
1 mL
Other Acceptable Specimens
Bone marrow collected in: Sodium heparin (green-top) tube, sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Evening Sets up 7 days a week.
Clinical Significance
The IGH-MAFB probe set is used to detect the t(14;20)(q32;q12) in patients with high-risk plasma cell myeloma (PCM).
This translocation is strongly associated with del(13q), hypodiploidy, and gain of 1q. However, patients with t(14;20) and monoclonal gammopathy, MGUS, or smoldering PCM, may have stable disease for years before progressing.
This translocation is strongly associated with del(13q), hypodiploidy, and gain of 1q. However, patients with t(14;20) and monoclonal gammopathy, MGUS, or smoldering PCM, may have stable disease for years before progressing.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042
