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Oxygen Dissociation, p50
Test CodeP50
Alias/See Also
Hemoglobin, Oxygen Dissociation Curve
Preferred Specimen
5 mL sodium heparin whole blood and 5 mL sodium heparin tube from a normal control
Minimum Volume
1 mL
Instructions
Normal control is drawn at the same time from a normal, unrelated, non-smoking individual. Label only as 'NORMAL CONTROL'. Refrigerate specimens immediately post draw and do not open tubes. Rubberband control and patient sample together. Specimens must reach reference lab within 72 hours of collection.
Transport Container
Original collection vial
Transport Temperature
Refrigerated
Specimen Stability
72 hours refirgerated
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
No control vial sent, lithium heparin tube
Report Available
2-4 days
Reference Range
24-30 mm Hg
Clinical Significance
Increased oxygen affinity of hemoglobin, reflected in a low p50, left-shifted oxygen dissociation curve, and loss of normal sigmoidal configuration, is characteristic of many hemoglobin variants that are responsible for polycythemia. Measurement of oxygen affinity is the most important method for diagnosis of these disorders.
