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RPR, QUALITATIVE w/REFLEX to TITER
MessageNote: This is a required test for Syphilis screening for CDC immigration requirements.
Test Code
LAB7940
Includes
- RPR
- RPR titer (if screen positive)
- Treponemal pallidum antibody (if screen positive)
Preferred Specimen
1 Gold tube (SST)
Minimum Volume
0.5 mL (1 mL optimal)
Other Acceptable Specimens
1 Green tube (Lithium Heparin)
OR
OR
Instructions
Centrifuge for complete separation of serum or plasma from red cells.
Transport Container
Transfer tube
Transport Temperature
Refrigerate
Specimen Stability
2-8°C up to 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Multiplex Flow Immunoassay
Setup Schedule
M, T, W, Th, F, Sa, Su
Batched; once per day, STAT testing is available
Batched; once per day, STAT testing is available
Report Available
Same day received
Reference Range
Non-Reactive
Positive results are reported to the Illinois Board of Health. Please note the physician has a separate reporting requirement independent from the laboratory.
A negative RPR result may present in cases of untreated, late, or latent Syphilis. Despite active Syphilis, serologic tests may be negative in severly immunosupressed patients. In very early cases of primary Syphilis, serology testing may be negative. Results should be considered in the context of all available clinical and laboratory data.
Assay interference resulting in false positive results may occur due to cross-reacting antibodies from patients diagnosed with Systemic Lupus Erythemoatosus (SLE), pregnancy, malaria, autoimmune disease, viral pneumonia, intravenous drug use and in people who have been recently immunized.
Positive results are reported to the Illinois Board of Health. Please note the physician has a separate reporting requirement independent from the laboratory.
A negative RPR result may present in cases of untreated, late, or latent Syphilis. Despite active Syphilis, serologic tests may be negative in severly immunosupressed patients. In very early cases of primary Syphilis, serology testing may be negative. Results should be considered in the context of all available clinical and laboratory data.
Assay interference resulting in false positive results may occur due to cross-reacting antibodies from patients diagnosed with Systemic Lupus Erythemoatosus (SLE), pregnancy, malaria, autoimmune disease, viral pneumonia, intravenous drug use and in people who have been recently immunized.
Clinical Significance
Useful for syphilis screening in patients LESS THAN 1 year of age. For patients OLDER THAN 1 year, clients are encouraged to follow the reverse algorithm (see link below) and order Syphilis Screening (SYPHB). In cases of untreated, late, or latent Syphilis, the RPR result may be negative. Reactive RPR results will reflex to RPR Titer and Treponemal pallidum antibody confirmation.
Performing Laboratory
Alverno Central Lab
Additional Information
Syphilis Testing Reverse Algorithm
