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HEMOGLOBIN ELECTROPHORESIS
MessageNote: This test should not be used for patients with a known diagnosis.
Test Code
LAB966
Alias/See Also
- Hemoglobin Evaluation
- Hemoglobin Fractionantion
CPT Codes
83020
Includes
- Hgb A
- Hgb F
- Hgb S
- Hgb A2
- Hgb C
- Hgb Other 1
- Hgb Other 2
- Hgb A2 Variant
- Pathologist Interpretation
- Sickledex test (on positive Hgb S)
Preferred Specimen
1 Lavender tube (EDTA
Patient Preparation
None
Minimum Volume
1 mL (4 mL optimal
Instructions
DO NOT CENTRIFUGE
Transport Container
Lavender tube
Transport Temperature
Refrigerate
Specimen Stability
2-8°C up to 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed
Methodology
Capillary Electrophoresis
Setup Schedule
M, T, W, Th, F
Batched
Batched
Report Available
Available the following day
Reference Range
Normal hemoglobin types include:
- Hemoglobin A (Hb A): makes up about 95%-98% of hemoglobin found in adults.
- Hemoglobin A2 (Hb A2 ): makes up about 2%-3% of hemoglobin found in adults.
- Hemoglobin F (Hb F, fetal hemoglobin): makes up to 1%-2% of hemoglobin found in adults. Hb F is the primary hemoglobin produced by the fetus during pregnancy. Production of Hb F falls shortly after birth and reaches adult level within 1-2 years.
Clinical Significance
Hemoglobin is the iron-containing protein compound within red blood cells that carries oxygen throughout the body. It is made up of heme, which is the iron-containing portion, and globin chains, which are proteins. Red blood cells containing abnormal hemoglobin may not carry oxygen efficiently and may have a shorter life span in the body.
Genetic changes in the globin genes cause alterations in the globin protein, resulting in a hemoglobin mutations such as hemoglobin S or hemoglobin C, among others. Hb S causes sickle cell disease and Hb C causes hemolytic anemia.
Genetic changes in the globin genes cause alterations in the globin protein, resulting in a hemoglobin mutations such as hemoglobin S or hemoglobin C, among others. Hb S causes sickle cell disease and Hb C causes hemolytic anemia.
Performing Laboratory
Alverno Central Lab
