FISH, Ewing/PNET, EWSR1, 22q12 Rearrangements

Test Code

FISH EWING (OE & LAB), QUEST (16112)

CPT Codes
88271 (x2), 88275

Preferred Specimen

Formalin-fixed, paraffin-embedded specimen or
3 mL of bone marrow collected in a sodium heparin (green-top) tube or
5x5 mm tissue biopsy collected in transport medium

Minimum Volume

1 mL

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Fluorescence in situ Hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Daily

Report Available

5-7 days

Clinical Significance

A FISH Ewing sarcoma assay by using the LSI (R) EWSR1 (22q12) Dual Color, Break Apart Rearrangement Probe (Vysis) to identify chromosomal rearrangements of the EWSR1 gene region.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.