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SYPHILIS SCREEN
MessageNote: The CDC recommends for immigration requirements that nontreponemal testing be performed to screen for Syphilis. Order RPR Qualitative w/Reflex to Titer.
Test Code
SYPHSCR (OE & LAB)
CPT Codes
86780, 86592 (RPR), 86593 (RPR titer), 86780 (TP-PA)
Includes
- Treponemal IgM and IgG Antibody
- RPR (if antibody positve)
- RPR titer (if antibody positive)
- Treponemal pallidum particulate agglutination (if antibody positive but RPR negative)
Preferred Specimen
1 Gold tube (SST)

Minimum Volume
0.5 mL (1 mL optimal)
Instructions
Centrifuge for complete separation of serum from red cells. Refrigerate until tested.
Transport Container
Transfer tube
Transport Temperature
Refrigerate
Specimen Stability
2-8°C up to 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Multiplex Flow Immunoassay
Setup Schedule
M, T, W, Th, F, Sa, Su
Batched; once per day
Batched; once per day
Reference Range
Non-Reactive
Reactive and Equivocal results are reported to the states of Indiana and Illinois Board of Health. Please note the physician has a separate reporting requirement independent from the laboratory.
Despite active Syphilis, serologic tests may be negative in severely immunosuppressed patients. In very early cases of primary Syphilis, serology testing may be negative. Results should be considered in the context of all available clinical and laboratory data.
Reactive and Equivocal results are reported to the states of Indiana and Illinois Board of Health. Please note the physician has a separate reporting requirement independent from the laboratory.
Despite active Syphilis, serologic tests may be negative in severely immunosuppressed patients. In very early cases of primary Syphilis, serology testing may be negative. Results should be considered in the context of all available clinical and laboratory data.
Performing Laboratory
Alverno Central Lab