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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
ANTIBODY TITER
Test CodeABT
Alias/See Also
Atypical Antibody (Specific) Titer ; Rh Titer
CPT Codes
86886
Includes
Antibody and Titer result
Preferred Specimen
Pink Tube
Minimum Volume
1mL (6mL optimal)
Other Acceptable Specimens
Lavender Tube
Instructions
Freeze remaining serum in case subsequent parallel titers are required.
Transport Container
One 6 mL pink top
Transport Temperature
Room Temperature
Specimen Stability
Store at 1-6 °C if not tested immediately. -30°C for long term storage, for future parallel titers.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimen drawn in wrong tube; grossly hemolyzed specimen; improperly labeled; quantity not sufficient for analysis
Methodology
Hemagglutination; Serial Dilution
Setup Schedule
Daily, 24 hours
Report Available
24 hours
Limitations
Titers do not always reflect the condition of an unborn child. Not indicated for antibodies which have not been known to cause hemolytic disease of the newborn (ie, IgM class antibodies in prenatal patients).
Reference Range
An increase of two doubling dilutions during pregnancy indicates consideration for amniocentesis. A titer of 1:16 can be considered critical for antibody.
Clinical Significance
Predict or diagnose hemolytic disease of the newborn due to red blood cell incompatibility during the course of a pregnancy.A rising titer during pregnancy is of more significance than a single assay. Titer =1:32, or a rising titer, or both, of an antibody capable of causing hemolytic disease of the newborn (HDN) are said to be indications to perform amniocentesis. Specific phenotype determinations on the father's red blood cells may be helpful.
Performing Laboratory
Mount Sinai Hospital
