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FISH, AML-NUP98 (11p15.4)
Test Code39966
CPT Codes
88271 (x2), 88275
Includes
If results are not possible from the submitted specimen, the test order will be cancelled and replaced by non-orderable test Cytogenetics Communication.
Preferred Specimen
5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume
3 mL whole blood • 1 mL bone marrow
Other Acceptable Specimens
Bone marrow collected in: Bone marrow transport tube (available upon request)
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 7 days a week.
Clinical Significance
Structural chromosomal rearrangements of the Nucleoporin 98 (NUP98) gene have been reported in a wide range of hematologic neoplasms including acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and T-cell acute lymphoblastic leukemia (T-ALL). Fusion of NUP98 gene to various fusion partners leads to generation of leukemogenic NUP98 fusion proteins and correlates with poor prognosis. The NUP98 FISH test will allow for the detection of NUP98 gene rearrangement to further classify prognostic risk in AML and guide therapy selection.