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SOX-11, IHC without Interpretation
Test Code12059
CPT Codes
88342
Preferred Specimen
Tissue collected in a formalin-fixed, paraffin-embedded block submitted in IHC specimen transport kit
Other Acceptable Specimens
1 unstained slide for each test requested plus 3-4 additional slides cut at 4 µm on positively (+) charged slides
Instructions
Please include surgical pathology report. Do not reject.
Send specimen to lab for testing determination.
Send specimen to lab for testing determination.
Transport Temperature
Room temperature
Specimen Stability
Paraffin block
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable
Slides
Room temperature: 45 days
Refrigerated: 45 days
Frozen: Unacceptable
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable
Slides
Room temperature: 45 days
Refrigerated: 45 days
Frozen: Unacceptable
Methodology
Immunohistochemistry Assay (IHC)
Setup Schedule
A.M. Sets up 7 days a week.
Report Available
Reports in 1 to 2 days.
Clinical Significance
SOX-11 is a transcription factor expressed in almost all cases of mantle cell lymphoma (MCL), including the rare entity cyclin D1-negative MCL. It is not expressed in potential MCL mimics such as atypical chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), follicular lymphoma, and marginal zone lymphoma (Soldini D, et al. Am J Surg Path 38:86-93, 2014).
Subcellular Localization: Nuclear
Subcellular Localization: Nuclear
