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VMA (Vanillylmandelic Acid), 24-Hour Urine without Creatinine
Test Code934X
CPT Codes
84585
Includes
CPT code 81050 may be added at an additional charge for volume measurement
Preferred Specimen
10 mL aliquot from a 24-hour urine preserved with 25 mL 6N HCl, collected in a plastic, 24-hour urine container
Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. However common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco (including use of nicotine patch), bananas, citrus fruits and strenuous exercise prior to collection.
Minimum Volume
5 mL
Other Acceptable Specimens
Aliquot from a 24-hour urine, unpreserved, with a pH ≤6, collected in a plastic, 24-hour urine container
Instructions
Collect 24-hour urine with 25 mL 6N HCL to maintain a pH < or = 3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be < or = 6. Record 24-hour urine volume and patient's age on test request form and on urine container.
Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen
Unpreserved urine: Frozen
Specimen Stability
Preserved urine:
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 1 year
Unpreserved urine:
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 1 year
Unpreserved urine:
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved urine received refrigerated with pH >3 • Unpreserved urine received frozen with pH >6
Methodology
High Performance Liquid Chromatography (HPLC) • Electrochemical Detection
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun-Fri; Report Available: 2-6 days
Clinical Significance
Vanillylmandelic Acid (VMA) is the major urinary project resulting from the metabolic degradation of catecholamine, norepinephrine and epinephrine. Elevated concentrations of VMA are commonly found in cases of catecholamine secreting tumors such as pheochromocytoma, neuroblastoma, and ganglioneuroma.
Drugs which can interfere with testing due to physiologic response: clonidine, L-dopa, methocarbamol, monoamine oxidase inhibitors, reserpine, salicylates.
Drugs which can interfere with testing due to physiologic response: clonidine, L-dopa, methocarbamol, monoamine oxidase inhibitors, reserpine, salicylates.